monkey CCR5 receptor is also validated for cAMP and radioligand binding competition assays

Target Information

Family :
Chemokine
Receptor :

CCR5

Species :
Macaca mulatta, Macaca fascicularis
Accession number :
AAB62554.1

Assay Information

Cat. Number :
FAST-0711A
Method :
luminescence
Assay Type :
aequorin (calcium)
Source :
CHO-K1-mt aequorin-Gα16

Testing Information

Mode:
agonist
Reference agonist:
CCL4 (MIP-1β)
EC50:
0.42nM*
#ALT#

Mode:
antagonist
Reference antagonist:
Maraviroc
IC50:
1.75nM*
#ALT#
Standard TAT :
15 Business Days
Fast TAT :
5 Business Days
* Value is subjected to variation from lot to lot