Orphan receptors panel

Profile your compounds against a panel of 76 orphan receptors. Receptors will be tested using the most appropriate readout when signaling has been confirmed through constitutive activity (GPR3, GPR6, GPR12, GPR21…) or the use of exogenous/surrogate ligands (GPR17, GPR52…). When no better alternative exists, receptors are tested in the highly sensitive Aequorin (calcium) readout with forced-coupling via a promiscuous Gα16 or a chimeric Gqi5.

Target	Assay	Target	Assay	Target	Assay
GPR3	cAMP	GPR61	cAMP	GPR161 (RE2)	cAMP
GPR4	cAMP	GPR62	cAMP	GPR162 (A-2)	AEQ
GPR6	cAMP	GPR63	AEQ	GPR171 (H963)	AEQ
GPR12	cAMP	GPR65	cAMP	GPR173 (SREB3)	AEQ
GPR17	cAMP	GPR68 (OGR1)	IPOne	GPR174 (DA6)	AEQ
GPR18	AEQ	GPR75	AEQ	GPR176 (HB954)	AEQ
GPR19 (GPR-NGA)	AEQ	GPR78	cAMP	GPR182 (HSGPCP)	AEQ
GPR20	AEQ	GPR82	AEQ	GPRC5A (RAIG1)	AEQ
GPR21	cAMP	GPR83 (GPR72)	AEQ	GPRC5B (RAIG2)	AEQ
GPR22	AEQ	GPR84	cAMP	GPRC5C (RAIG3)	AEQ
GPR23 (LPAR4)	AEQ	GPR87 (HG03)	IPOne	GPRC5D (RAIG4)	AEQ
GPR25	AEQ	GPR88	cAMP	LPA₅ (GPR92)	IPOne
GPR26	cAMP	GPR91	AEQ	MAS	AEQ
GPR27 (SREB1)	AEQ	GPR99	AEQ	MRG	AEQ
GPR30 (GPER)	AEQ	GPR101	cAMP	MRGD	AEQ
GPR31	AEQ	GPR139	AEQ	MRGE	AEQ
GPR32	AEQ	GPR141	AEQ	MRGF (RTA)	AEQ
GPR34	cAMP	GPR142	IPOne	P2Y5	AEQ
GPR35	cAMP	GPR146	AEQ	P2Y8	AEQ
GPR37	AEQ	GPR148	AEQ	P2Y10	AEQ
GPR37L1	AEQ	GPR149	AEQ	TAAR2 (GPR58)	cAMP
GPR39	AEQ	GPR150	AEQ	TAAR5 (PNR)	cAMP
GPR45	AEQ	GPR151	AEQ	TAAR6 (TA4)	cAMP
GPR50	AEQ	GPR152	AEQ	TAAR8 (TA5)	cAMP
GPR52	cAMP	GPR153	AEQ	TAAR9 (TA3)	cAMP
GPR55	AEQ

Custom profile

If you don’t find a profiling that suits your needs, don’t hesitate to contact us and let us know what you are looking for. We’ll be happy to help you out and design a tailor-made panel!