Safety panel

Profile your compounds against a panel of 44 GPCR, ion channel, transporters and enzymes for potential safety issues.

GPCR

Family	Target	Readout	Family	Target	Readout
Adenosine	A2A	Binding	Histamine	H2	Binding
Adrenergic	α1a	Binding	Melatonin	MT1	Binding
	α2a	Binding		MT2	Binding
	β2	Binding	Muscarinic	Non selective	Binding
Cannabinoid	CB1	Binding	Serotonin	5-HT1A	Binding
Dopamine	D1	Binding		5-HT1B	Binding
	D2S	Binding		5-HT2A	Binding
Opioid	σ	Binding		5-HT2B	Binding
	δ	Binding	Cholecystokinin	CCK1	Binding
	κ	Binding	Endothelin	ETA	Binding
	μ	Binding		ETB	Binding
Histamine	H1	Binding	Vasopressin	V1a	Binding

Transporters

Family	Target	Readout
Amine transporter	DAT	Binding
	NET	Binding
	SERT	Binding

Ion channels

Family	Target	Readout
Ca²⁺ channel	L-type, DHP site	Binding
	L-type, Verapamil site	Binding
K⁺ channel	hERG	Binding
Serotonin	5-HT₃	Binding
GABA	BZD (Central)	Binding
NMDA	GRIN1	Binding
Nicotinic	α4β2	Binding

Enzymes

Family	Target	Readout
Acetylcholinesterase	AChE	Fluorescence
Cyclooxygenase	COX-2	Colorimetric
Monoamine Oxidase	MAO-A	Luminescence
Phosphodiesterase	PDE-3	HTRF
Phosphodiesterase	PDE-4	HTRF
Cytochrome P450	CYP1A2	Luminescence
	CYP2C9	Luminescence
	CYP2D6	Luminescence
	CYP2E1	Luminescence
	CYP3A4	Luminescence

Custom profile

If you don’t find a profiling that suits your needs, don’t hesitate to contact us and let us know what you are looking for. We’ll be happy to help you out and design a tailor-made panel!