57 GPCR Diversity panel

Profile the activity of your GPCR modulator over a broad panel representing the main receptor families. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.

Target Natural coupling Assay Target Natural coupling Assay
Serotonin 5-HT1A Gi/o cAMP Leukotrien CysLT1 Gq/11 AEQ
Serotonin 5-HT1B Gi/o cAMP Dopamine D1 Golf, Gs cAMP
Serotonin 5-HT2A Gq/11 AEQ Dopamine D2 Gi/o GTPγS
Serotonin 5-HT2B Gq/11 AEQ Dopamine D3 Gi/o GTPγS
Serotonin 5-HT2Cne Gq/11 AEQ Dopamine D4.4 Gi/o GTPγS
Serotonin 5-HT3 Ion channel AEQ Endothelin ETA Gq/11, Gs AEQ
Serotonin 5-HT4e Gs cAMP Endothelin ETB Gq/11, Gi/o AEQ
Serotonin 5-HT5a Gi/o AEQ Ghrelin GHS-R Gq/11 AEQ
Serotonin 5-HT6 Gs cAMP Histamine H1 Gq/11 AEQ
Serotonin 5-HT7 Gs cAMP Histamine H2 Gs cAMP
Adenosine A1 Gi/o cAMP Histamine H3 Gi/o GTPγS
Adenosine A2A Gs cAMP Motilin MTL Gq/11 AEQ
Adenosine A3 Gi/o cAMP Muscarinic M1 Gq/11 AEQ
Adrenergic beta1 Gs cAMP Muscarinic M2 Gi/o GTPγS
Adrenergic beta2 Gs cAMP Muscarinic M3 Gq/11 AEQ
Adrenergic  alpha1A Gq/11 AEQ Muscarinic M4 Gi/o GTPγS
Adrenergic  alpha1B Gq/11 AEQ Muscarinic M5 Gq/11 AEQ
Adrenergic  alpha2A Gi/o GTPγS Nociceptin OFQ (NOP) Gi/o GTPγS
Adrenergic  alpha2B Gi/o GTPγS Neurokinin NK1 Gq/11 AEQ
Adrenergic  alpha2C Gi/o GTPγS Neurokinin NK2 Gq/11 AEQ
Angiotensin AT1 Gq/11 AEQ Neuropeptide NPY1 Gi/o cAMP
Bradykinin B1 Gq/11 AEQ Opioid OP1 Gi/o GTPγS
Cannabinoid CB1 Gi/o cAMP Opioid OP2 Gi/o GTPγS
Cannabinoid CB2 Gi/o cAMP Opioid OP3 Gi/o GTPγS
Cholecystokinin CCK1 Gq/11, Gs AEQ Somatostatin sst4 Gi GTPγS
Cholecystokinin CCK2 Gq AEQ Urotensin-II Gq/11 AEQ
Calcitonin CGRP Gq/11, Gs AEQ Vasopressin V1a Gq/11 AEQ
Chemokine CXCR1 Gi/o GTPγS Vasopressin V1b Gq/11 AEQ

Custom profile

If you don’t find a profiling that suits your needs, don’t hesitate to contact us and let us know what you are looking for. We’ll be happy to help you out and design a tailor-made panel!

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